Wise Woman Clinic Research,

ROB1 - Process for obtaining a shark cartilage extract - Google Patents

Dermatology facing autoinflammatory syndrome Mihail Alecu, Gabriela Coman, Alina Musetescu, Marian Emanuel Cojoaca, Oana Andreia Coman Cutaneous symptoms are characteristic for the autoinflammatory disorders AIDsboth in the classical autoinflammatory phenotype and in most disorders included in this syndrome, but they are not specific and inconstant.

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Several skin disorders pyoderma gangrenosum and pustular acne may be encountered either isolate or associated with autoinflammatory symptoms, forming well-defined clinical entities within the autoinflammatory syndrome. The high prevalence of cutaneous manifestations is an important characteristic of AIDs. The presence of cutaneous symptoms in AIDs opens the perspective of understanding the Site uri de afaceri de afaceri of innate immunity mechanisms involved in skin pathology.

It is possible that many diseases present the alteration, in various degrees, of the innate immune mechanisms. Recently, dermatology faced two challenges connected to AIDs. The first involves the diagnosis of skin symptoms in a clinical autoinflammatory setting and the investigative approach to identify a disorder classified as AID.

The second is Wise Woman Clinic Research identify the altered mechanisms of inborn immunity among the pathogenetic mechanisms of known dermatological diseases e.

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On Wise Woman Clinic Research other hand, cutaneous symptoms are in certain cases regarded as a criterion to asses the efficacy of specific or non-specific therapies with monoclonal antibodies in disorders included in AIDs. Dermatology mostly benefits from the identification and knowledge of AIDs due to the role of innate immunity in skin pathogeny and also due to the large extent of clinical forms resulting from the association of skin symptoms with other disorders included in this group.

Corresponding author: Coman Gabriela, PhD; e-mail: noime85 yahoo. Research in renal tumor pathogenesis is currently oriented on the genetic and proteins framework of the renal cell carcinoma, with the aim to translate the level of knowledge on tumor subtypes from histological to molecular issues, simultaneously with the deciphering of the manner in which the signaling pathways intervene in the pathogenic mechanism.

Alterations identified in proto-oncogenes and tumor suppressor genes lead to abnormal and deficient transmission of signal in the signaling pathways, and initiate the carcinogenesis mechanism by increased proliferation of tumor cells. Although it seems obvious that the classic sequence of carcinogenesis is respected at the renal site, unfortunately, the manner in which signaling pathways are involved, in the specific context of renal tumors, is not extensively investigated.

The pathogenic mechanisms of AD remain elusive and treatment options unsatisfactory, targeting only symptoms like memory loss, behavior changes, sleep disorders and seizures.

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These therapies are not stopping the disease s progression, at their best they can only delay it. Accumulating evidence suggests that AD is associated with a microglial dysfunction. Microglia are resident immune cells that provide continuous surveillance within the brain.

When excessively activated, microglial response can also have detrimental effects via the exacerbation of inflammatory processes and release of neurotoxic substances.

Recently, it was recognized that microglia express voltage-gated ion channels, in particularly voltage-gated sodium channels VGSC. Pharmacological block of VGSC has been attempted symptomatically in AD to control the epileptic features often associated with AD, as well as to relieve detrimental behavioral and psychological symptoms of dementia.

This variability could not be satisfactorily explained solely by the neuronal effects.

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This article will try to discuss possible implication of microglial VGSC dysfunction in AD according to available data, own personal experience of the authors and propose a new way to investigate its possible implications. An overview of permanent vascular access in hemodialyzed patients Ionel Alexandru Checherita, Liliana Ana Tuta, Cristiana David, Ileana Peride, Andrei Niculae, Bogdan Florin Geavlete, Catalin Pricop, Daniela Adriana Ion In the last decade, because of significant number of end-stage renal disease individuals in need of renal therapy replacement and permanent quest of Wise Woman Clinic Research to optimize kidney disease patients quality of life, there is an increased interest in achieving a suitable permanent vascular access, essential for an efficient dialysis.

Furthermore, it is of high importance Wise Woman Clinic Research preserve arteriovenous fistula in optimal condition and therefore, it is vital to correctly understand the histopathology and pathophysiological mechanisms implicated in maturation and well function of dialysis vascular access. Morphological and quantitative study of collagen fibers in healthy and diseased human gingival tissues Tatiane Almeida, Thalita Valverde, Paulo Martins-Junior, Heder Ribeiro, Gregory Kitten, Lorenza Carvalhaes Objectives: This study aimed to evaluate types I, III and IV collagen in healthy gingival tissue and to compare them to gingival tissues suffering from chronic gingivitis and chronic periodontitis.

Materials and Methods: Thirty-two man patients were selected. The patients belonged to three diagnostic categories: healthy gingiva HGchronic gingivitis CG and chronic periodontitis CPbased on clinical and radiographical criteria.

Gingival tissue samples were obtained from patients who underwent periodontal surgery procedures.

Congenital infections may have various outcomes, from intrauterine death to clinically asymptomatic infections. The treatments of ToRCH infections in pregnancy are directed to reducing maternal symptoms and preventing maternal-to-child transmission of pathogens. The early recognition and the prenatal approach for congenital infections are key aspects in the management of ToRCH infections.

Hematoxylin and Eosin HEPicrosirius red, indirect immunofluorescence by confocal microscopy and quantitative analyses were performed to identify the presence and location of types I, III and IV collagen. Statistical significance was verified using the Kruskal-Wallis test.

Results: Samples from HG group showed thick collagen fibers arranged in a parallel pattern.

Samples from CG group showed dilated blood vessels; collagen fibers and inflammatory cells were found dispersed throughout the tissue. Samples from CP group showed the extracellular matrix severely damaged, disorganized collagen fibers and large amount of inflammatory cells. The types III and IV collagen fibers showed no difference in expression in tissues with gingivitis and periodontitis.

Conclusions: Following the periodontal disease there was a morphological destruction of the extracellular matrix with lower expression of collagen, which led to a change in tissue architecture that might compromise its functional capacity.

There were differences in type I collagen expression among healthy, chronic gingivitis and chronic periodontitis tissue samples. The underlying mechanisms have remained elusive, but endogenous neurogenesis and perilesional angiogenesis have been speculated to contribute to the behavioral improvement.

To address this question, neurogenesis in the subventricular zone SVZ and perilesional angiogenesis RECA-1 were correlated with behavioral performance Wise Woman Clinic Research forty Wistar rats subjected to transient middle cerebral artery occlusion MCAO or sham-operation.

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MCAO rats and sham-operated rats housed in single non-enriched cages were used as controls. Histological analysis after day behavioral follow-up showed a massive increase in doublecortin DCX -positive cells in the SVZ both in MCAO rats housed in single cages and in the enriched environment together with atipamezole treatment whereas perilesional RECA-1 staining for new blood vessels was not altered.

Time to the first contact and time to remove sticky stimuli from the forelimbs indicated improved sensory processing, which disappeared after cessation of atipamezole administration.

Skilled forelimb use as measured by performance in Montoya s staircase test was not affected by the treatment. There were no correlations between behavioral measures and histology. Thus, sensory facilitation or reversal of hypometabolism by the combined therapy may be the mechanism accounting for the improved behavior after stroke independent from neurogenesis and angiogenesis.

Corresponding author: Jukka Jolkkonen, PhD; e-mail: jukka. Heterogeneity of collagen secreting cells in gingival fibrosis - an immunohistochemical assessment and a review of the literature Eugen Ionut Pascu, Catalina Gabriela Pisoschi, Ana-Marina Andrei, Maria Cristina Munteanu, Anne-Marie Rauten, Monica Scrieciu, Oana Taisescu, Mihai Surpateanu, Ileana Monica Banita Aim: In this work, we compared the histological features of the gingival lesions clinically diagnosed as fibrotic overgrowths due to various etiologic factors as well as an immunohistochemical assessment of Wise Woman Clinic Research phenotypic heterogeneity using the specific labeling for vimentin, alpha-smooth muscle actin alpha-SMA and fibroblast specific protein-1 FSP1.

Materials and Methods: Tissue samples were obtained from 12 patients clinically diagnosed with fibrotic gingival Wise Woman Clinic Research, divided in four groups.

Fragments of gingiva were processed for paraffin embedding. Results: Storage of collagen fibers, increase of fibroblast number and frequent presence of inflammatory infiltrate are histological issues of all fibrotic gingival overgrowth.

The incidence of granulation tissue varies but the frequency of its presence point the attention to the involvement in collagen metabolism imbalance. Immunostaining for vimentin showed a difference between its expression in samples from different groups.

Except the cases of fibrosis induced by orthodontic devices, cells positive for alpha-SMA were rare. FSP1-positive fibroblasts were the most frequent in all cases from all the groups selected for this study.

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Conclusions: Wise Woman Clinic Research Wise Woman Clinic Research of fibroblasts is different in gingival fibrosis in relation to the risk factor, at present the most common being vimentin-positive and FSP1-positive fibroblasts.

Myofibroblasts are rare in gingival fibrosis, the most numerous being in local lesions caused by wearing orthodontic devices and in syndromic fibromatosis.

Further studies are required to elucidate the manner in which the active Wise Woman Clinic Research are recruited in relation to the Wise Woman Clinic Research factor of gingival overgrowth. Materials and Methods: Fourteen female patients with idiopathic hirsutism that followed an antiandrogen treatment with CPA were biopsied from the androgen-dependent area of the chin before and 12 months after the treatment. Routine sections were stained with Hematoxylin-Eosin, Masson, Van Gieson, Sirius red and picric-indigocarmine, while additional sections were immunostained for S protein and vimentin.

Electron microscopy was performed in two cases with Langerhans cell hyperplasia. Results: On biopsies-stained sections, an increased number of hair follicles, the deeper part of the epithelial sheath of the hair follicle with epithelial buds, hyperplasia of sebaceous glands, and no inflammatory infiltrate were noticed.

Langerhans cells identified with S protein and vimentin were normal in terms of numbers and distribution.

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After the administration of the treatment, atrophy of the pilo-sebaceous units was visible in nine In six of the cases treated with antiandrogens, a marked hyperplasia of Langerhans cells was noticed. In conclusion, the benefit of antiandrogen treatments is supported by atrophy of the Wise Woman Clinic Research follicle and the sebaceous glands.

The activation of Langerhans cells associated with inflammatory infiltrate in the dermis and hair follicles could be considered as a local consequence of the involution process of hair follicles after the administration of the treatment.

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Curcumin is a diarylheptanoid antitumoral drug while it significantly inhibits cell migration, invasion, and colony formation in vitro and reduces tumor growth and liver metastasis in vivo. Curcumin photoactivation may enhance antiapoptotic role against cancer cells. Aim: To evaluate the effect of low curcumin concentrations, ranged from 1.

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A secondary aim was to evaluate the ideal method Wise Woman Clinic Research produce easy-to-use tumor cell spheroids, comparing two low adherence plate supports.

Materials and Methods: Breast adenocarcinoma cell line MDA-MB were cultured according to 2D monolayer and 3D spheroid models then submitted to normal and photoactivated curcumin in micromolar concentrations.

RO118567B1 - Process for obtaining a shark cartilage extract - Google Patents

MTT assay was used to evaluate cell viability following curcumin application on cells. On 2D cell cultures, curcumin inhibits cell tumor development and proliferation at concentrations of 15 micro-M, with a viability of Curcumin photoactivation increases pro-apoptotic effects in both 2D and 3D tumor cell culture models and also responsiveness to curcumin is slightly reduced in spheroid-like structures. Thus, 3D tumor cell culture systems appear to be the ideal environment for in vitro assays regarding anticancer drug effects on cell viability.

The role of some biological mediators in periodontal disease was widely investigated, especially that of MMP-8 and MMP Recently, MMP-2 was also considered to be an appropriate therapeutic target for prevention Wise Woman Clinic Research periodontal disease progression.

Gingival samples obtained from patients with no pharmacological treated chronic periodontitis and those receiving either the association between amoxicillin-metronidazole and spyramicin-metronidazole were processed for paraffin embedding and then used to perform immunohistochemical reactions in order to detect MMP-2 and TIMP All subjects were evaluated clinically and radiographic at the first visit and after treatment completed, the Loe and Silnees gingival index at six sites per tooth for the whole Wise Woman Clinic Research being recorded.

Statistical analysis was performed using non-parametrical techniques. Gingiva samples from untreated chronic periodontitis patients revealed a diffuse positive reaction for MMP-2 in the epithelium and also in fibroblasts and macrophages from the lamina propria.

For gingiva samples from patients treated with antibiotics, MMP-2 positive reaction was restricted to deep epithelial layers and few cells of the connective tissue. No significant difference was observed for TIMP-2 expression. The clinical indexes were in accordance with immunohistochemical results.

Description Translated from Romanian Invenția se referă la procedeul de obținere al unui extract de cartilagiu de rechin utilizat în medicină. The invention relates to the process for obtaining a shark cartilage extract used in medicine. Cartilagiul este un țesut nevascularizat și a fost studiat drept un candidat potențial conținând factori antiangiogenici. El este, de asemenea, un țesut relativ rezistent la dezvoltarea tumorilor.

Our study investigated simultaneously the differences in expression of the two markers, in different tumoral compartments, according to the prognostic parameters of the Wise Woman Clinic Research. The study indicated significant differences in the expression of E-cadherin in relation to tumor grade, depth of invasion, tumor stage and Ki proliferation index PIboth intratumoral and at the advancing edge. For CD44, expression differences were found between the tumor grades in intratumoral sites, while for both intratumoral and advancing edge compartments the differences occurred for the depth of tumor invasion, tumor stage and Ki PI.

The only differences in the expression of the two markers in relation with the presence of lymph node metastasis were for E-cadherin at the advancing edge.

The maintenance of CD44 expression at the advancing edge represents a negative prognostic factor for bladder urothelial carcinoma and supports the implication of EMT process, through the existence at this level of a cell population with particular properties.

Netea, Cornel Catoi Toll-like receptor 4 TLR4 signaling is involved in various acute and chronic renal lesions and contributes to inflammation and fibrosis in several organs; the latter are important determinants to the progression of chronic kidney disease CKD. We aimed to assess TLR4 expression in progressive Wise Woman Clinic Research and relate it to severity of kidney damage, using an experimental nephron reduction model.

Male Wistar rats were subjected to subtotal nephrectomy using the ligation technique, after 12 weeks of observation, serum creatinine and proteinuria were determined, animals were sacrificed, glomerulosclerosis and interstitial scarring were quantified histologically, and TLR4 expression was assessed by immunohistochemistry. Sham-operated rats served as controls.

Case animals had significantly higher creatinine, proteinuria, glomerulosclerosis and tubulointerstitial involvement. TLR4 expression was prominent in proximal tubes, less staining was observed on infiltrating inflammatory cells.

Percentage of TLR4-positive tubes was reduced in the subtotal nephrectomy animals, when compared to controls 0. As TLR4 staining appears in tubular casts only in nephrectomy animals, shedding from damaged tubular cells is a very likely explanation for the reduced TLR4 expression in the kidneys of subjects with experimental nephron reduction.

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The tumor necrosis factor alpha TNF-alpha represents an important inflammation mediator associated to carcinogenesis and even to tumor progression. We evaluated the seric values of TNF-alpha in a group of patients with tonsil cancer in comparison to a group of patients with chronic tonsillitis, as well as the reaction of mastocytes and macrophages in the two types of tonsil lesions. In the patients undergoing radiotherapy, the TNF-alpha seric levels were within normal limits.

There were not observed any significant differences between the two types of tonsil lesions, regarding the macrophages and mast cells density on the surface unit.

I think I became acutely aware of it on my first trip abroad. On an Air France bus on the way from CDG to Paris there was a video about sex tourism and how countries were banding together to stop it and imprison offenders. That same night a man approached me when I was alone on a Paris street at night and eventually tried to get me into his car to drive me back to my hotel. Of course I fled. A couple years later, I moved to Paris.

Histone acetylation regulates the expression of HoxD9 transcription factor in endothelial progenitor cells Florin Iordache, Andrei Constantinescu, Eugen Andrei, Horia Maniu The homeobox Hox genes encode transcription factors that are involved in the morphogenesis of body.

Recent data showed that the HoxD transcription factors control the cardiovascular system development, by modulation of endothelial cell proliferation and differentiation. For our knowledge, the role of histone acetylation in expression of HoxD9 has not been studied to date; therefore, the aim of this study was to investigate the expression of HoxD9 in endothelial progenitor cells after treatment with valproic acid VPAa histone deacetylase inhibitor. Our results showed that VPA inhibits the histone deacetylases leaving chromatin in an acetylated state corresponding to a decondensate conformation.